Use of 10% Lipid Emulsion to Reverse Ventricular Fibrillation Following Of an Iatrogenic Local Anesthetic Overdose: A Case Report

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Use of lipid emulsion therapy in local anesthetic overdose

The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although findings are contradictory. Efficiency of ILE was demonstrated in animal studies in the treatment of sev...

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Lipid Emulsion for Local Anesthetic Systemic Toxicity

The accidental overdose of local anesthetics may prove fatal. The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death. Local anesthetics are the most frequently used drugs amongst anesthetists and although uncommon, local anaesthetic systemic toxicity accounts for a high proportion of mortality, with lo...

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Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose.

I T seems implausible that an injection of a simple, off-theshelf, intravenous nutritional solution could be acutely life-saving for a patient with severe drug overdose. But dozens of published case reports support this observation, first made more than a decade ago in a rodent model of bupivacaine toxicity. It is even more surprising that such a simple formulation can rapidly reverse severe cl...

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ژورنال

عنوان ژورنال: Pharmaceutica Analytica Acta

سال: 2015

ISSN: 2153-2435

DOI: 10.4172/2153-2435.1000398